Frequently asked questions

Common
Questions

Always read the full Instructions for Use accompanying your medication, and contact your healthcare professional if you have any questions.

About Dupixent

Dupixent is used to treat children (6-11 years of age) with severe atopic eczema (atopic dermatitis), and adolescents and adults (12 years and older) with moderate-to-severe atopic eczema (atopic dermatitis), who are candidates for systemic therapy.

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The active ingredient of Dupixent is dupilumab, a monoclonal antibody (a type of specialised protein) that blocks the action of proteins called IL-4 and IL-13. Both play a major role in causing the signs and symptoms of atopic dermatitis. This medicine may be used with atopic eczema medicines that you apply to the skin or it may be used on its own.

Using this medicine for atopic dermatitis can improve the condition of your son or daughter’s skin and reduce itching. This medicine has also been shown to improve symptoms of pain, anxiety, and depression associated with moderateto-severe atopic dermatitis. In addition, it may help improve your son or daughter’s sleep disturbance and quality of life.

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Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date that is stated on the label and carton after EXP. The expiry date refers to the last day of that month. Store in a refrigerator (2°C to 8°C). Pre-filled syringes or pens may be kept at room temperature for a maximum of 14 days. Do not store above 25°C. Do not freeze. Store in the original carton to protect from light. Do not use this medicine if you notice that the medicine is cloudy, discoloured, or has particles in it.

Precautions
Do not use Dupixent if your son or daughter is, or you think is, allergic to dupilumab or any of the other ingredients of this medicine. If you think your son or daughter may be allergic, or you are not sure, ask your healthcare professional for advice before using this medicine.

Pregnancy and breast-feeding
If your daughter is pregnant, thinks she may be pregnant, or is planning to have a baby, ask your healthcare professional for advice before using this medicine. The effects of this medicine in pregnant women are not known; therefore, it is preferable to avoid the use of Dupixent in pregnancy unless your healthcare professional advises to use it. If she is planning to breast-feed, your healthcare professional should decide if she will breast-feed or use this medicine. She should not do both.

Asthma
If your son or daughter has asthma and is taking asthma medicines, do not change or stop the asthma medicine without talking to their healthcare professional.

Allergic reactions
Very rarely, Dupixent can cause serious side effects, including allergic (hypersensitivity) reactions. You must look out for signs of these conditions such as breathing problems, swelling of the face, mouth and tongue, fainting, dizziness, feeling lightheaded (low blood pressure), fever, general ill feeling, swollen lymph nodes, hives, itching, joint pain, skin rash while you are taking this medicine. Stop using this medicine and tell your son or daughter’s healthcare professional or get medical help immediately if you notice any signs of an allergic reaction. These reactions can occur from minutes up to seven days after Dupixent administration.

Eosinophilic conditions
Rarely patients taking an asthma medicine may develop inflammation of blood vessels or lungs due to an increase of certain white blood cells (eosinophilia). Tell your doctor immediately if your son or daughter develops a combination of symptoms such as a flu-like illness, pins and needles or numbness of the arms or legs, worsening of pulmonary symptoms, and/or rash.

Parasitic (intestinal parasites) infection
Dupixent may weaken your son or daughter’s resistance to infections caused by parasites. If your son or daughter already has a parasitic infection, it should be treated before starting treatment with this medicine. Check with your healthcare professional if your son or daughter has diarrhoea, gas, upset stomach, greasy stools, and dehydration which could be a sign of a parasitic infection. If you live in a region where these infections are common or if you and your son or daughter are travelling to such a region, check with your healthcare professional.

Eye problems
Talk to your healthcare professional if your son or daughter has any new or worsening eye problems, including eye pain or changes in vision.

Vaccinations
Talk to your healthcare professional if your son or daughter has recently had or is due to have a vaccination.

Please refer to the Patient Information Leaflet in the pack for full safety information.

GET MORE SAFETY INFORMATION

Dupixent can cause serious side effects, including very rare allergic reactions. The signs of allergic reaction may include, breathing problems, swelling of the face, lips, mouth or tongue, fainting, dizziness, feeling lightheaded, fever, feeling unwell, swollen lymph nodes, hives, itching, joint pain or skin rash.

Very Common (may affect more than 1 in 10 people):
  • Injection site reactions (ie, redness, swelling, and itching)
Common (may affect up to 1 in 10 people):
  • Headache
  • Eye dryness, redness, and itching
  • Eyelid itching, redness, and swelling
  • Eye infection
  • Cold sores (on lips and skin)
Uncommon (may affect up to 1 in 100 people):
  • Inflammation of the eye surface, sometimes with blurred vision (keratitis, ulcerative keratitis).

Reporting of side effects

Dupixent is subject to additional monitoring. This will allow quick identification of new safety information. If your son or daughter gets any side effects, talk to your healthcare professional. This includes any possible side effects not listed in the package leaflet. You can also report side effects directly via the Yellow Card Scheme at www.mhra.gov.uk/yellowcard.

By reporting side effects, you can help provide more information on the safety of this medicine.

GET MORE SAFETY INFORMATION

Dosing

Dupixent is given by injection under the skin. Your healthcare professional decides if your son or daughter should inject this medicine or if you should do it. Always use this medicine exactly as your healthcare professional has explained.

Inject this medicine only after your son, daughter or you have been trained by your healthcare professional.

You and your son or daughter can inject into your son or daughter’s thigh or belly (stomach), except for the 5 cm around the navel. You can also use your son or daughter’s upper arm if you are doing the injection. Change the injection site for each injection. Do not inject into skin that is tender, damaged or has bruises or scars. Ensure you have the following: the Dupixent pre-filled syringe or pen, 1 alcohol wipe, 1 cotton ball or gauze, and a punctureresistant container. Please follow all instructions outlined in the Instructions for Use in the Dupixent pack and ask your healthcare professional if you have any questions.

VIEW INSTRUCTIONS

Your healthcare professional will decide how much Dupixent your son or daughter needs and for how long.

For children (6-11) with a body weight of 15 to < 60 kg, the recommended first dose is 300 mg (one 300 mg injection) on Day 1, then 300 mg on Day 15, followed by 300 mg every 4 weeks by subcutaneous injection.

This dose may be changed to 200 mg every 2 weeks based on their clinician’s assessment.

For children with a body weight of 60 kg or more, the recommended first dose is 600 mg (two 300 mg injections), followed by 300 mg every other week by subcutaneous injection.

For adolescent (12-17) with body weight under 60 kg, the recommended first dose is 400 mg (two 200 mg injections consecutively in different injection sites), followed by 200 mg given every two weeks by subcutaneous injection.

For adolescents with body weight 60 kg or more, the recommended first dose is 600 mg (two 300 mg injections consecutively in different injection sites), followed by 300 mg given every two weeks by subcutaneous injection.

If you administer more Dupixent than you should, or forget to administer Dupixent, please contact your son or daughter’s healthcare professional immediately.

Dupixent is subject to additional monitoring. This will allow quick identification of new safety information. If your son or daughter gets any side effects, talk to your healthcare professional. This includes any possible side effects not listed in the package leaflet. You can also report side effects directly via the Yellow Card Scheme at www.mhra.gov.uk/yellowcard.

Your healthcare professional will decide how much Dupixent your son or daughter needs and for how long. Do not stop using Dupixent without speaking to your healthcare professional first.

Because of the chronic (recurring) nature of atopic dermatitis, the inflammation that causes your son or daughter’s flare-ups may still be present beneath the surface of the skin, even if no flares are visible. So you should continue to inject Dupixent as prescribed, even if your son or daughter’s skin looks clear, to continue the clinical benefits of the medicine.

How to Travel with Dupixent

It is important to keep your son or daughter’s treatment in mind when you are planning a trip so that he or she can continue to take Dupixent exactly as directed by their healthcare professional. Please contact their healthcare professional before travelling.

  • Make sure you have enough of this medicine to last the entire trip. Take an extra prescription for Dupixent in case you lose the medication or it becomes damaged.
  • Make sure the injection schedule is marked on your calendar or programmed into your smartphone prior to the trip so your son or daughter can take their medicine on time.
  • Pack an adequate supply of alcohol wipes, cotton gauze, and a puncture-resistant container.
  • Because this medicine requires storage in a refrigerator (2–8°C), ensure you have access to refrigeration during your travels.
  • Use an insulated storage pack with cold packs to keep this medicine between 2–8°C prior to putting it in a refrigerator on an aeroplane (for example, getting to the airport, waiting to board the flight).
  • Consider bringing a thermometer so you can verify the temperature is kept at 2–8°C.
  • Dupixent must not be frozen. Store this medicine away from the freezer section and avoid contact with ice.
  • Keep in mind that this medicine can be stored at room temperature (25°C) for a single maximum period of 14 days. If you do not use it within 14 days, you must discard it.
  • If you're planning on travelling, please speak to your healthcare professional or homecare company for additional advice.

HealthNet Homecare
Contact: dupixent@healthnethomecare.co.uk
Number: 0800 092 7720
Between Monday - Friday 8am to 5:30pm

Lloyds Pharmacy Clinical Homecare
Contact: lpch.ccc@nhs.net
Number: 0247 662 5573
Between Monday - Friday 8am to 5:30pm

Healthcare at Home
Contact: hah.enquiries@hah.co.uk
Number: 0333 207 9915
Between Monday - Friday 8am to 5:30pm

  • Let your airline know you will need to keep the medication refrigerated before, during, and after your flights. You will also need to arrange insulated cold pack storage as needed.
  • Pack the medicine in your carry-on baggage to avoid possible loss in the event checked baggage gets lost or damaged.
  • Liquid prescription medications are exempt from the onboard liquid restrictions in some countries, but you will still need to declare them during security screening.
  • Keep this medicine in its original packaging with its pharmacy label and your son or daughter’s name. This can help airport security verify the product as his or her prescription medication and its requirement for refrigerated storage. It will also protect it from light.
  • Alcohol wipes may be easier to transport than rubbing alcohol, since you will need to declare rubbing alcohol at airport security.
  • Consider calling your airport well in advance of your trip, if you have questions about local regulations.

Health information contained herein is provided for general educational purposes only. Your healthcare professional is the single best source of information regarding your health. Please consult your healthcare professional if you have any questions about your health or treatment.