How to Take DUPIXENT

Taking
Dupixent

Use Dupixent exactly as prescribed by your healthcare professional. Your healthcare professional will tell you how much Dupixent to inject and how often to inject it.

Dupixent is available as a single-dose pre-filled syringe or as a single dose pre-filled pen. Do not try to inject this medicine until you have been shown the right way by your healthcare professional.

Select the correct option below to see the supplemental injection training video.

DOWNLOAD PATIENT INFORMATION GUIDE 1.9 MB



PRE-FILLED PEN CAREGIVER INJECTION

Narration: On Camera Opening:
Mum: Hi there. Thanks for watching. Today we’re going to show you how to properly inject a dose DUPIXENT (dupilumab), using the singledose pre-filled pen.

Since you’ve already learned how to self-inject with your healthcare provider, I’ll be here to guide your through your first at-home experience.

When I first started giving injections, I found it intimidating, but with a little practice and help from our healthcare provider, I’ve gotten much better at the process, and I want to share these steps with you, today.

First thing we’ll go over is: What supplies to gather, How to prep the injection area, and How to inject the dose and discard your single-use, pre-filled pen.

If you haven’t yet read the instructions for use located in your DUPIXENT treatment package, pause the video and take a look. Please read all the instructions carefully, before using the pre-filled pen.

Narration:
The steps for using the DUPIXENT single-dose pre-filled pen are the same for the 200mg and 300mg dosage strengths. In this video I’ll show you how to use the 300mg pen, so the device you are using may appear different than what you see in this video, based on your prescribed dose. If you have any questions about the dosage prescribed, please contact your healthcare provider.

Let’s take a closer look at the pre-filled pen. I found it helpful to review the different parts of the pre-filled pen, like the cap, the window and the needle cover, before handling the pre-filled pen itself. The colors on your device may vary from what you see here.

Contact your healthcare provider or the DUPIXENT Patient Support with any questions. They’re always there to help.

Narration: On camera:
Mum: OK, it’s time for your DUPIXENT injection. Are you ready?

Daughter: Yeah.

Mum: Feel free to watch us and follow along as I give an injection

Narration:
To begin, take your medication out of the refrigerator

  • Keep the pre-filled pen and all medicines out of the reach of children
  • Keep unused pre-filled pens in the original carton and store in the refrigerator between 2° to 8°C or 36° to 46° F

Take one pen out of the packaging by holding the middle of the pen body

Now, let’s check the label on the pen to ensure that the medication and dosage strengths are correct and the expiration date has not passed. Do not use the pen if the expiration date has passed. If the dosage strength or expiration date isn’t right, contact your pharmacy.

Next, take a look at the medicine through the viewing window. The liquid inside should be clear and colourless, to pale yellow. You may see an air bubble. This is totally normal.

  • Do not inject DUPIXENT if the liquid inside is discolored or cloudy, or contains visible flakes or particles
  • Do not use the pre-filled pen if the window is solid yellow
  • Do not use the pre-filled pen if it has been damaged
  • Do not use the pre-filled pen if the cap is missing or not securely attached

If you have any questions about whether the pen is okay to use, please call the DUPIXENT Patient Support or your healthcare provider.

If you have an unused pre-filled pen, return it to the refrigerator in the original carton to protect it from light.

Lay the pre-filled pen on a flat surface and let it naturally warm to a room temperature. The recommended warming time for the 200mg pen is 30 minutes and for the 300mg pen it is 45 minutes.

  • Do not freeze or heat the pre-filled pen
  • Do not put the pre-filled pen into direct sunlight
  • Throw away any used pre-filled pen that has been left at room temperature for more than 14 days.
  • Do not shake the pre-filled pen at any time

As the pen warms up, let’s gather some additional materials you’ll need to self-inject. You’ll need a cotton ball or gauze, an alcohol wipe, and a puncture resistant disposal container.

If you don’t have a puncture resistant disposal container call your pharmacy, healthcare provider or Dupixent Patient Support to request a puncture resistant disposal container.

We’re almost ready to inject DUPIXENT.

First, let’s wash our hands thoroughly with soap and water.

Now, take your supplies to an area where you can sit comfortably. I prefer the comfort of our living room couch, you might prefer the bathroom, or your bedroom for privacy

Next, let’s choose an injection site. Both the stomach and thigh are acceptable, except for the 5 cm or 2 in around your belly button.

The outer area of the upper arm is also an option since you are giving the injection to someone, but not if you are self-injecting.

Be sure to choose a different site each time you inject DUPIXENT.

  • Do not inject through clothes.
  • Do not inject into skin that is tender, damaged, bruised or scarred

Now, clean the skin with the alcohol wipe.

Do not touch the injection site again or blow on it before the injection. Let your skin dry before injection.

Pick up the pen by holding the middle of the pen body with the needle pointing away from you. With your other hand, pull the cap straight off.

Once you have removed the cap, do not put it back on.

  • Do not twist the cap of
  • Do not remove the cap until you are ready to inject
  • Do not press or touch the needle cover with your fingers, the needle is inside.
  • Do not try to put the cap back on once you’ve removed it.

Place the needle cover on the skin at approximately a 90-degree angle. Make sure you can see the injector window.

Press down and hold the pen firmly against the skin until you can no longer see the needle cover. There will be a “click” when the injection starts.

As you hold the pen firmly against the skin, the injector window will start to turn yellow. The injection can take up to 20 seconds.

You will hear a second “click”. Check to see if the entire window has turned yellow before removing the pen. Slowly count to 5 and lift the pen straight up off the skin.

That’s it! You’re done!

If the window does not turn fully yellow, remove the pen and call your healthcare provider. Do not give a second dose without speaking to your healthcare provider.

Lightly press a cotton ball or gauze on the injection site if you see any blood. You can also cover the site with a bandage. If the bleeding doesn’t stop, contact your healthcare provider.

  • Do not rub your skin after the injection

Be sure to put the used pen and its cap into a puncture-resistant disposal container right away after use.

  • Do not re-use the pre-filled pen
  • Do not dispose of pre-filled pens in your household trash
  • Do not recycle your used puncture-resistant container

Follow your local guidelines and ask your pharmacy or healthcare provider for the appropriate way to dispose of your used pen.

Be sure to keep track of your injection date and site.

Narration: On camera:
Thank you for joining us today.

Remember, you can re-watch this video as often as you like to refresh your memory

Contact your healthcare provider or DUPIXENT Patient Support with any questions or concerns.

Pre-filled Syringe Instructions

  1. STEP
    Remove

    Remove the syringe from the carton by holding the middle of the syringe body

    • Do not pull off the needle cap until you are ready to inject.
    • Do not use the syringe if it has been damaged.

  2. STEP
    Prepare

    Ensure you have the following:

    • the Dupixent pre-filled syringe.
    • 1 alcohol wipe*
    • 1 cotton ball or gauze*
    • a puncture-resistant container* (See Step 12)

    * Items not included in the carton

    Look at the label:

    • Check the expiry date
    • Check that you have the correct product and dose
    • Do not use the syringe if the expiry date has passed.
    • Do not keep Dupixent at room temperature for more than 14 days.

  3. STEP
    Inspect

    Look at the medicine through the viewing window on the syringe:

    • Check if the liquid is clear and colourless to pale yellow.
    • Note: You may see an air bubble; this is normal.
    • Do not use the syringe if the liquid is discoloured or cloudy, or if it contains flakes or particles.

  4. STEP
    Wait 45 minutes*
    Lay the pre-filled syringe on a flat surface for at least 45 minutes and let it get to room temperature naturally
    • Do not heat the syringe.
    • Do not place the syringe in direct sunlight.
    • Do not keep Dupixent at room temperature for more than 14 days.

    * For the 200mg pre-filled syringe, lay on a flat surface for at least 30 minutes

  1. 5STEP
    Choose
    Select the injection site. Choose your injection site
    • You can inject into the thigh or belly (stomach) except for the 5 cm around the navel (belly button)
    • If you are giving the injection, you can also use the upper arm
    • Change the injection site for each injection.
    • Do not inject into skin that is tender, damaged or has bruises or scars.

  2. STEP
    Clean
    • Wash your hands
    • Clean the injection site with an alcohol wipe
    • Let the skin dry before injecting
    • Do not touch the injection site again or blow on it before the injection.

  3. STEP
    Pull
    • Hold the syringe in the middle of the syringe body with the needle pointing away from you and pull off the needle cap.
    • Do not put the needle cap back on.
    • Do not touch the needle.
    • Inject the medicine immediately after removing the needle cap.
  1. STEP
    Pinch
    Pinch

    Pinch a fold of skin at the injection site, as shown in picture.


  2. STEP
    Insert
    Insert

    Insert the needle completely into the fold of skin at roughly a 45º angle.


  3. STEP
    Push
    Push
    • Relax the pinch
    • Push the plunger rod down slowly and steadily as far as it will go, until the Dupixent Syringe is empty
    • Note: You will feel some resistance. This is normal.

  4. STEP
    Release and Remove
    Release and Remove
    • Lift your thumb to release the plunger rod until the needle is covered by the needle shield and then remove the syringe from the injection site
    • Lightly press a cotton ball or gauze on the injection site if you see any blood
    • Do not put the needle cap back on.
    • Do not rub your skin after the injection.

  5. STEP
    Dispose
    • Dispose of the syringe and the needle cap in a puncture-resistant container
    • Do not put the needle cap back on.
    • Always keep the container out of the reach of children.

Important Information

This medicine can be self-administered, or administered by a parent or carer at home, and so it contains a needle. It is supplied in the form of a single-use Dupixent pre-filled syringe. You must not try to give someone else the injection unless you have received training from their healthcare professional.

  • Read all of the instructions carefully before using the syringe
  • Check with your son or daughter’s healthcare professional how often you will need to inject the medicine.
Do
  • Ask your healthcare professional to show you the right way to use the syringe before you administer the injection for the first time
  • Alternate the injection site for each injection
  • Keep the syringe(s) out of the reach of children
  • Keep unused syringes in the original carton and store in the refrigerator between 2°C and 8°C
  • Keep the syringes in the original carton to protect the medicine from light.
Do not
  • Do not use the syringe if it has been dropped on a hard surface or damaged
  • Do not use the syringe if the needle cap is missing or not securely attached
  • Do not touch the plunger rod until you are ready to inject
  • Do not inject through clothes
  • Do not get rid of any air bubbles in the syringe
  • Never pull back on the plunger rod
  • Do not reuse the syringe
  • Do not shake the syringe at any time
  • Do not store above 25°C
  • Do not keep Dupixent at room temperature (above fridge temperature and below 25°C) for more than 14 days. If you need to permanently remove the carton from the refrigerator, write down the date of removal in the space provided on the outer carton, and use Dupixent within 14 days
  • Do not heat the syringe
  • Do not freeze the syringe
  • Do not place the syringe into direct sunlight.

F.A.Qs

Find out more about Dupixent dosage, storage, and more.

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