Narration: On Camera Opening:
Mum: Hi there. Thanks for watching. Today we’re going to show you how to properly inject a dose DUPIXENT (dupilumab), using the singledose pre-filled pen.
Since you’ve already learned how to self-inject with your
healthcare provider, I’ll be here to guide your through your
first at-home experience.
When I first started giving injections, I found it intimidating, but with a little practice and help from our healthcare provider, I’ve gotten
much better at the process, and I want to share these steps with you, today.
First thing we’ll go over is: What supplies to gather, How to prep the injection area, and How to inject the dose and discard your single-use,
If you haven’t yet read the instructions for use located in your DUPIXENT treatment package, pause the video and take a look. Please read
all the instructions carefully, before using the pre-filled pen.
The steps for using the DUPIXENT single-dose pre-filled pen are the same for the 200mg and 300mg dosage strengths. In this video I’ll
show you how to use the 300mg pen, so the device you are using may appear different than what you see in this video, based on your
prescribed dose. If you have any questions about the dosage prescribed, please contact your healthcare provider.
Let’s take a closer look at the pre-filled pen. I found it helpful to review the different parts of the pre-filled pen, like the cap, the window
and the needle cover, before handling the pre-filled pen itself. The colors on your device may vary from what you see here.
Contact your healthcare provider or the DUPIXENT Patient Support with any questions. They’re always there to help.
Narration: On camera:
Mum: OK, it’s time for your DUPIXENT injection. Are you ready?
Mum: Feel free to watch us and follow along as I give an injection
To begin, take your medication out of the refrigerator
- Keep the pre-filled pen and all medicines out of the reach of children
- Keep unused pre-filled pens in the original carton and store in the refrigerator between 2° to 8°C or 36° to 46° F
Take one pen out of the packaging by holding the middle of the pen body
Now, let’s check the label on the pen to ensure that the medication and dosage strengths are correct and the expiration date has not
passed. Do not use the pen if the expiration date has passed. If the dosage strength or expiration date isn’t right, contact your pharmacy.
Next, take a look at the medicine through the viewing window. The liquid inside should be clear and colourless, to pale yellow. You may see
an air bubble. This is totally normal.
- Do not inject DUPIXENT if the liquid inside is discolored or cloudy, or contains visible flakes or particles
- Do not use the pre-filled pen if the window is solid yellow
- Do not use the pre-filled pen if it has been damaged
- Do not use the pre-filled pen if the cap is missing or not securely attached
If you have any questions about whether the pen is okay to use, please call the DUPIXENT Patient Support or your healthcare provider.
If you have an unused pre-filled pen, return it to the refrigerator in the original carton to protect it from light.
Lay the pre-filled pen on a flat surface and let it naturally warm to a room temperature. The recommended warming time for the 200mg
pen is 30 minutes and for the 300mg pen it is 45 minutes.
- Do not freeze or heat the pre-filled pen
- Do not put the pre-filled pen into direct sunlight
- Throw away any used pre-filled pen that has been left at room temperature for more than 14 days.
- Do not shake the pre-filled pen at any time
As the pen warms up, let’s gather some additional materials you’ll need to self-inject. You’ll need a cotton ball or gauze, an alcohol wipe,
and a puncture resistant disposal container.
If you don’t have a puncture resistant disposal container call your pharmacy, healthcare provider or Dupixent Patient Support to request a
puncture resistant disposal container.
We’re almost ready to inject DUPIXENT.
First, let’s wash our hands thoroughly with soap and water.
Now, take your supplies to an area where you can sit comfortably. I prefer the comfort of our living room couch, you might prefer the
bathroom, or your bedroom for privacy
Next, let’s choose an injection site. Both the stomach and thigh are acceptable, except for the 5 cm or 2 in around your belly button.
The outer area of the upper arm is also an option since you are giving the injection to someone, but not if you are self-injecting.
Be sure to choose a different site each time you inject DUPIXENT.
- Do not inject through clothes.
- Do not inject into skin that is tender, damaged, bruised or scarred
Now, clean the skin with the alcohol wipe.
Do not touch the injection site again or blow on it before the injection. Let your skin dry before injection.
Pick up the pen by holding the middle of the pen body with the needle pointing away from you. With your other hand, pull the cap straight off.
Once you have removed the cap, do not put it back on.
- Do not twist the cap of
- Do not remove the cap until you are ready to inject
- Do not press or touch the needle cover with your fingers, the needle is inside.
- Do not try to put the cap back on once you’ve removed it.
Place the needle cover on the skin at approximately a 90-degree angle. Make sure you can see the injector window.
Press down and hold the pen firmly against the skin until you can no longer see the needle cover. There will be a “click” when the
As you hold the pen firmly against the skin, the injector window will start to turn yellow. The injection can take up to 20 seconds.
You will hear a second “click”. Check to see if the entire window has turned yellow before removing the pen. Slowly count to 5 and lift the
pen straight up off the skin.
That’s it! You’re done!
If the window does not turn fully yellow, remove the pen and call your healthcare provider. Do not give a second dose without speaking to
your healthcare provider.
Lightly press a cotton ball or gauze on the injection site if you see any blood. You can also cover the site with a bandage. If the bleeding
doesn’t stop, contact your healthcare provider.
- Do not rub your skin after the injection
Be sure to put the used pen and its cap into a puncture-resistant disposal container right away after use.
- Do not re-use the pre-filled pen
- Do not dispose of pre-filled pens in your household trash
- Do not recycle your used puncture-resistant container
Follow your local guidelines and ask your pharmacy or healthcare provider for the appropriate way to dispose of your used pen.
Be sure to keep track of your injection date and site.
Narration: On camera:
Thank you for joining us today.
Remember, you can re-watch this video as often as you like to refresh your memory
Contact your healthcare provider or DUPIXENT Patient Support with any questions or concerns.