Always read the full Patient Information Guide and Instructions for Use accompanying your medication, and contact your healthcare professional if you have any questions.
Dupixent is used to treat adults and adolescents 12 years and older with moderate-to-severe atopic eczema (atopic dermatitis) who are candidates for systemic therapy. This medicine contains the active substance dupilumab.Get the Facts
The active ingredient of Dupixent is dupilumab, a monoclonal antibody (a type of specialised protein) that blocks the action of proteins called IL-4 and IL-13. Both play a major role in causing the signs and symptoms of atopic dermatitis. This medicine may be used with atopic eczema medicines that you apply to the skin or it may be used on its own.
Using this medicine for atopic dermatitis can improve the condition of your skin and reduce itching. This medicine has also been shown to improve symptoms of pain, anxiety, and depression associated with moderate-to-severe atopic dermatitis. In addition, it may help improve your sleep disturbance and quality of life.Get the Facts
Keep this medicine out of the sight and reach of children.
Do not use this medicine after the expiry date that is stated on the label and carton after EXP. The expiry date refers to the last day of that month. Store in a refrigerator (2°C to 8°C). Pre-filled syringes or pens may be kept at room temperature for a maximum of 14 days. Do not store above 25°C. Do not freeze. Store in the original carton to protect from light. Do not use this medicine if you notice that the medicine is cloudy, discoloured, or has particles in it.
Dupixent is a registered trademark of Sanofi and Regeneron Pharmaceuticals.
Do not use Dupixent if you are or think you are allergic to dupilumab or any of the other ingredients of this medicine. If you think you may be allergic, or you are not sure, ask your healthcare professional for advice before using this medicine.
Pregnancy and breast-feeding
If you're pregnant, think you may be pregnant, or are planning to have a baby, ask your healthcare professional for advice before using this medicine. The effects of this medicine in pregnant women are not known; therefore, it is preferable to avoid the use of Dupixent in pregnancy unless your healthcare professional advises to use it. If you are planning to breast-feed, you and your healthcare professional should decide if you will breast-feed or use this medicine. You should not do both.
If you have asthma and are taking asthma medicines, do not change or stop your asthma medicine without talking to your healthcare professional.
Very rarely, Dupixent can cause serious side effects, including allergic (hypersensitivity) reactions. You must look out for signs of these conditions (such as fever, general ill feeling, swollen lymph nodes, hives, itching, joint pain, and skin rash) while you are taking this medicine. Stop using this medicine and tell your healthcare professional or get medical help immediately if you notice any signs of an allergic reaction.
Parasitic (intestinal parasites) infection
Dupixent may weaken your resistance to infections caused by parasites. If you already have a parasitic infection, it should be treated before you start treatment with this medicine. Check with your healthcare professional if you have diarrhea, gas, upset stomach, greasy stools, and dehydration which could be a sign of a parasitic infection. If you live in a region where these infections are common or if you are traveling to such a region, check with your healthcare professional.
Talk to your healthcare professional if you have any new or worsening eye problems, including eye pain or changes in vision.
Talk to your healthcare professional if you have recently had or are due to have a vaccination.
Please refer to the Patient Information Leaflet in the pack for full safety information.Get More Safety Information
Reporting of side effects By reporting side effects, you can help provide more information on the safety of this medicine.
Dupixent is subject to additional monitoring. This will allow quick identification of new safety information. If you get any side effects, talk to your healthcare professional. This includes any possible side effects not listed in the package leaflet. You can also report side effects directly via the Yellow Card Scheme at www.mhra.gov.uk/yellowcard.
By reporting side effects, you can help provide more information on the safety of this medicine.Get More Safety Information
Dupixent is given by injection under your skin. You and your healthcare professional should decide if you should inject this medicine yourself. Always use this medicine exactly as your healthcare professional has told you.
Inject this medicine yourself only after you have been trained by your healthcare professional. A caregiver may also give you an injection after proper training.
You can inject into your thigh or belly (stomach), except for the 5 cm around your navel. If somebody else gives you the injection, they can also use your upper arm. Change the injection site for each injection. Do not inject into skin that is tender, damaged, or has bruises or scars. Ensure you have the following: Dupixent pre-filled syringe or pen, 1 alcohol wipe, 1 cotton ball or gauze, and a puncture-resistant container. Please follow all instructions outlined in the Instructions for Use, and ask your healthcare professional if you have any questions.View Instructions
For adults, the recommended first dose is 600mg (two 300 mg injections consecutively in different injection sites), followed by 300 mg given every two weeks by subcutaneous injection.
For adolescents with body weight under 60kg, the recommended first dose is 400mg (two 200 mg injections consecutively in different injection sites), followed by 200 mg given every two weeks by subcutaneous injection.
For adolescents with body weight of 60kg or more, the recommended first dose is 600mg (two 300 mg injections consecutively in different injection sites), followed by 300 mg given every two weeks by subcutaneous injection.
If a dose is missed, if you use more of this medicine than you should, or the dose has been given too early, talk to your doctor, pharmacist, or nurse.
Your healthcare professional will decide how much you need and for how long. Do not stop using this medicine without speaking to your healthcare professional first.
Because of the chronic (recurring) nature of atopic dermatitis, the inflammation that causes your flare-ups may still be present beneath the surface of your skin, even if no flares are visible. So you should continue to take this medicine as prescribed, even if your skin looks clear, to continue the clinical effects of the medicine.
Health information contained herein is provided for general educational purposes only. Your healthcare professional is the single best source of information regarding your health. Please consult your healthcare professional if you have any questions about your health or treatment.