How to Take DUPIXENT

Taking
Dupixent

Use Dupixent exactly as prescribed by your healthcare professional. If your healthcare professional decides that you or your caregiver can give the injections of this medicine, you or your caregiver should receive training on the right way to prepare and inject it. Do not try to inject this medicine until you have been shown the right way by your healthcare professional.


DOWNLOAD PATIENT INFORMATION GUIDE 6.9 MB


Watch the video below for additional information on how to use and dispose of this medicine.

Dupixent Auto-Injector Self Injection Video Script

Narration: On Camera Opening:
Hey, I’m Tom. Thanks for watching. Today I’m going to show you how to properly self-inject a dose of DUPIXENT (dupilumab), using the single-dose pre-filled pen.

Since you’ve already learned how to self-inject with your healthcare provider, I’ll be here to guide your through your first at-home experience.

To some, self-injections can be intimidating. I was nervous when I first started, but with some practice and help from my healthcare provider, I’ve gotten much better at the process, and I want to share those steps with you, today.

First thing we’ll go over is: What supplies to gather, How to prep the injection area, and How to inject the dose and discard your single-use, pre-filled pen.

If you haven’t yet read the instructions for use located in your DUPIXENT treatment packaging, pause the video and take a look. Please read all the instructions carefully, before using the pre-filled pen.

Narration:
The steps for treating yourself with the DUPIXENT single-dose pre-filled pen are the same for the 200mg and 300mg dosage strengths. In this video I’ll show you how to use the 300mg pen, so your device may appear different than what you see in this video, based on your prescribed dose. If you have any questions about the dosage prescribed, please contact your healthcare provider.

Let’s take a closer look at the pre-filled pen. I found it helpful to review the different parts of the pre-filled pen, like the cap, the window and the needle cover, before handling the pre-filled pen itself. The colors on your device may vary from what you see here.

Contact your healthcare provider or DUPIXENT patient support with any questions. They’re always there to help.

Narration: On Camera:
Ok, it’s time for me to take my DUPIXENT Injection. Feel free to watch me and follow along as I self-inject.

Narration:
To begin, take your medication out of the refrigerator.

  • Keep the pre-filled pen and all medicines out of the reach of children
  • Keep unused pre-filled pens in the original carton and store in the refrigerator between 2°-8°C [or 35°-46° F]

Take one pen out of the packaging by holding the middle of the pen body.

Now, let’s check the label on the pen to ensure that the medication and dosage strength are correct and the expiration date has not passed.

Do not use the pen if the expiration date has passed. If the dosage strength or expiration date isn’t right, contact your pharmacy.

Next, take a look at the medicine through the viewing window. The liquid inside should be clear and colorless, to pale yellow. You may see an air bubble. This is totally normal.

  • Do not inject DUPIXENT if the liquid inside is discolored or cloudy, or contains visible flakes or particles
  • Do not use the pre-filled pen if the window is solid yellow
  • Do not use the pre-filled pen if it has been damaged
  • Do not use the pre-filled pen if the cap is missing or not securely attached

If you have any questions about whether the pen is okay to use, please call DUPIXENT patient support or your healthcare provider.

If you have an unused pre-filled pen, return it to the refrigerator in the original carton to protect it from light.

Lay the pre-filled pen on a flat surface and let it naturally warm to room temperature.

The recommended warming time for the 200mg pen is 30 minutes, and for the 300mg pen, it's 45 minutes.

  • Do not freeze or heat the pre-filled pen
  • Do not put the pre-filled pen into direct sunlight
  • Do not keep DUPIXENT at room temperature for more than 14 days
  • Throw away any pre-filled pen that has been left at room temperature for more than 14 days
  • Do not shake the pre-filled pen at any time

As the pen warms up, let’s gather some additional materials you’ll need to self-inject. You’ll need a cotton ball or gauze, an alcohol wipe, and a puncture resistant disposal container.

If you don’t have a puncture resistant disposal container, call your pharmacy, healthcare provider, or DUPIXENT patient support to request a puncture resistant disposal container.

We’re almost ready to inject DUPIXENT.

First, let’s wash our hands thoroughly with soap and water.

Now, take your supplies to an area where you can sit comfortably. I prefer the comfort of my living room couch, you might prefer the bathroom, or your bedroom for privacy.

Next, let’s choose an injection site. Both the stomach and thigh are acceptable, except for the 5 cm around your belly button.

If a caregiver gives you the injection, the outer area of the upper arm is also an option. The person giving the injection should follow the same preparation procedure.

Be sure to choose a different site each time you inject DUPIXENT.

  • Do not inject through clothes
  • Do not inject into skin that is tender, damaged, bruised or scarred

Now, clean your skin with the alcohol wipe.

Do not touch the injection site again or blow on it before the injection.

Let your skin dry before injection.

Identify the hand you will hold the pen with while you give the injection. With this hand, hold the pen in the middle of the pen body with the needle pointing away from you. With the other hand, pull the cap straight off. Once you have removed the cap, do not put it back on.

  • Do not twist the cap off
  • Do not remove the cap until you are ready to inject
  • Do not press or touch the needle cover with your fingers
  • Do not try to put the cap back on once you’ve removed it
  • Inject the medicine right away after removing the cap

Place the needle cover on your skin at approximately a 90-degree angle. Make sure you can see the injector window.

Press down and hold the pen firmly against your skin until you can no longer see the needle cover. There will be a “click” when the injection starts.

As you hold the pen firmly against your skin, the injector window will start to turn yellow. The injection can take up to 20 seconds.

You may hear a second “click”. Check to see if the entire window has turned yellow before removing the pen. Slowly count to 5 and then lift the pen straight up off the skin. That’s it! You’re done.

If the window does not turn fully yellow, remove the pen and call your healthcare provider. Do not give yourself a second dose without speaking to your healthcare provider.

Lightly press a cotton ball or gauze on the injection site if you see any blood. You can also cover the site with a bandage. If the bleeding doesn’t stop, contact your healthcare provider.

  • Do not rub your skin after the injection.

Be sure to put the used pen and its cap into a puncture-resistant disposal container right away after use.

  • Do not re-use the pre-filled pen
  • Do not throw away the used pen in your household waste
  • Do not recycle your used puncture-resistant container
  • Follow your local guidelines and ask your healthcare provider for the appropriate way to dispose of the container once it is full.

    Follow your local guidelines and ask your pharmacy or healthcare provider for the appropriate way to dispose of your used pen.

    Narration: On Camera:
    Be sure to keep track of your injection date and site.

    Thank you for joining me today. Remember, you can re-watch this video as often as you like to refresh your memory.

    Contact your healthcare provider or DUPIXENT patient support with any questions or concerns.

Pre-filled pen: Self-injection instructions

The instructions below will help reinforce the steps your healthcare professional showed you. Remember, Do not try to inject this medicine until you have been shown the right way to do it by your healthcare professional.

Pre-filled syringe: Self-injection instructions

The instructions below will help reinforce the steps your healthcare professional showed you. Remember, Do not try to inject this medicine until you have been shown the right way to do it by your healthcare professional.

  1. STEP
    Prepare

    Ensure you have the following:

    • the Dupixent pre-filled pen
    • 1 alcohol wipe*
    • 1 cotton ball or gauze*
    • a puncture-resistant container* (See Step 11)

    * Items not included in the carton.

    Look at the label:

    • Check the expiry date
    • Check that you have the correct product and dose
    • Do not use the pre-filled pen if the expiry date has passed.
    • Do not keep Dupixent at room temperature for more than 14 days.
  2. STEP
    Inspect

    Look at the medicine through the viewing window on the pre-filled pen:

    • Check if the liquid is clear and colourless to pale yellow
    • Note: You may see an air bubble; this is normal.
    • Do not use the pre-filled pen if the liquid is discoloured or cloudy, or contains flakes or particles.
    • Do not use the pre-filled pen if the window is yellow.
  1. STEP
    Wait 45 minutes*
    Lay the pre-filled pen on a flat surface for at least 45 minutes and let it get to room temperature naturally.
    • Do not heat the pre-filled pen.
    • Do not place the pre-filled pen in direct sunlight.

    * For the 200mg pre-filled pen, lay on a flat surface for at least 30 minutes

  2. STEP
    Choose
    Select the injection site. Choose your injection site
    • You can inject into your thigh or belly (stomach) except for the 5 cm around your navel (belly button)
    • If somebody else gives you the injection, they can also use your upper arm
    • Change the injection site for each injection
    • Do not inject into skin that is tender, damaged or has bruises or scars.
  1. STEP
    Clean
    • Wash your hands
    • Clean the injection site with an alcohol wipe
    • Let your skin dry before injecting
    • Do not touch the injection site again or blow on it before the injection.
  2. STEP
    Pull
    Pull the cap straight off.
    • Do not twist the cap off.
    • Do not remove the cap until you are ready to inject.
    • Do not press or touch the needle cover with your fingers. The needle is inside.
    • Do not put the cap back on the pre-filled pen after you have removed it.
  1. STEP
    Place
    Place

    When placing the needle cover on your skin, hold the pre-filled pen so that you can see the window. Place the needle cover on your skin at approximately a 90-degree angle.

  2. STEP
    Press down
    Press down

    Press the pre-filled pen firmly against your skin until you cannot see the needle cover, and hold. There will be a “click” when the injection starts. The window will start to turn yellow. The injection can take up to 20 seconds.

  1. STEP
    Hold firmly
    Hold firmly

    Keep holding the pre-filled pen firmly against your skin. You may hear a second click. Check that the entire window has turned to yellow, then slowly count to 5. Then lift the pen up off the skin, your injection is complete.

    If the window does not turn completely yellow, remove the pen and call your healthcare provider.

    • Do not give yourself a second dose without speaking to your healthcare provider.
  2. STEP
    Remove
    Remove

    After you have completed your injection pull straight up to remove pre-filled pen from the skin. If you see any blood at the site, lightly dab a cotton ball or gauze pad.

    • Do not rub your skin after the injection.
  1. STEP
    Dispose
    • Dispose of the pre-filled pen, (needle inside), and cap in a puncture resistant container right away after use.
    • Do not put the green cap back on.
    • Always keep the container out of the reach of children.

Important Information

This medicine can be self-administered. It is supplied in the form of a single-use pre-filled pen. You must not try to give yourself or someone else the injection unless you have received training from your healthcare professional.

  • Read all of the instructions carefully before using the pre-filled pen.
  • Check with your healthcare professional how often you will need to inject the medicine.
  • Ask your healthcare professional to show you the right way to use the pre-filled pen before you inject for the first time.
  • Change the injection site for each injection.
  • Do not use the pre-filled pen if it has been damaged.
  • Do not use the pre-filled pen if the needle cap is missing or not securely attached.
  • Do not press or touch the needle cover with your fingers.
  • Do not inject through clothes.
  • Do not remove the cap until just before you give the injection.
  • Do not try to put the cap back on the pre-filled pen.
  • Do not re-use the pre-filled pen.

How to Store Dupixent

  • Keep the pre-filled pen out of the reach of children.
  • Keep unused pre-filled pen in the original carton and store in the refrigerator between 2ºC and 8ºC.
  • Do not keep Dupixent at room temperature (above fridge temperature and below 25ºC) for more than 14 days. If you need to permanently remove the carton from the refrigerator, write down the date of removal in the space provided the outer carton, and use Dupixent within 14 days.
  • Do not shake the pre-filled pen at any time.
  • Do not heat the pre-filled pen.
  • Do not freeze the pre-filled pen.
  • Do not place the pre-filled pen into direct sunlight.
  1. STEP
    Remove
    Remove the syringe from the carton by holding the middle of the syringe body.
    • Do not pull off the needle cap until you are ready to inject.
    • Do not use the syringe if it has been damaged.
  2. STEP
    Prepare

    Ensure you have the following:

    • the Dupixent pre-filled syringe
    • 1 alcohol wipe*
    • 1 cotton ball or gauze*
    • a puncture-resistant container* (See Step 12)

    * Items not included in the carton

    Look at the label:

    • Check the expiry date
    • Check that you have the correct product and dose
    • Do not use the syringe if the expiry date has passed.
    • Do not keep Dupixent at room temperature for more than 14 days.
  1. STEP
    Inspect

    Look at the medicine through the viewing window on the syringe:

    • Check if the liquid is clear and colourless to pale yellow.
    • Note: You may see an air bubble; this is normal.
    • Do not use the syringe if the liquid is discoloured or cloudy, or if it contains flakes or particles.
  2. STEP
    Wait 45 minutes*
    Lay the syringe on a flat surface for at least 45 minutes and let it get to room temperature naturally.
    • Do not heat the syringe.
    • Do not place the syringe in direct sunlight.
    • Do not keep Dupixent at room temperature for more than 14 days.

    * For the 200mg pre-filled syringe, lay on a flat surface for at least 30 minutes

  1. STEP
    Choose
    Select the injection site. Choose your injection site
    • You can inject into your thigh or belly (stomach), except for the 5 cm around your navel (belly button)
    • If somebody else gives you the injection, they can also use your upper arm
    • Change the injection site for each injection
    • Do not inject into skin that is tender, damaged or has bruises or scars.
  2. STEP
    Clean
    • Wash your hands
    • Clean the injection site with an alcohol wipe
    • Let your skin dry before injecting
    • Do not touch the injection site again or blow on it before the injection.
  1. STEP
    Pull
    • Hold the syringe in the middle of the syringe body with the needle pointing away from you and pull off the needle cap.
    • Do not put the needle cap back on.
    • Do not touch the needle.
    • Inject your medicine right away after removing the needle cap.
  2. STEP
    Pinch
    Pinch

    Pinch a fold of skin at the injection site, as shown in picture.

  1. STEP
    Insert
    Insert

    Insert the needle completely into the fold of skin at roughly a 45º angle.

  2. STEP
    Push
    Push
    • Relax the pinch.
    • Push the plunger rod down slowly and steadily as far as it will go, until the Dupixent Syringe is empty.
    • Note: You will feel some resistance. This is normal.
  1. STEP
    Release and Remove
    Release and Remove
    • Lift your thumb to release the plunger rod until the needle is covered by the needle shield and then remove the syringe from the injection site
    • Lightly press a cotton ball or gauze on the injection site if you see any blood
    • Do not put the needle cap back on.
    • Do not rub your skin after the injection.
  2. STEP
    Dispose
    • Dispose of the syringe and the needle cap in a puncture-resistant container
    • Do not put the needle cap back on.
    • Always keep the container out of the reach of children.

Important Information

This medicine can be self-administered and so it contains a needle. It is supplied in the form of a single-use Dupixent pre-filled syringe. You must not try to give yourself or someone else the injection unless you have received training from your healthcare professional.

  • Read all of the instructions carefully before using the syringe.
  • Check with your healthcare professional how often you will need to inject the medicine.
  • Ask your healthcare professional to show you the right way to use the syringe before you inject for the first time.
  • Change the injection site for each injection.
  • Do not use the syringe if it has been damaged.
  • Do not use the syringe if the needle cap is missing or not securely attached.
  • Do not touch the plunger rod until you are ready to inject.
  • Do not inject through clothes.
  • Do not get rid of any air bubbles in the syringe.
  • Never pull back on the plunger rod.
  • Do not re-use the syringe.

How to Store Dupixent

  • Keep the syringe(s) out of the reach of children.
  • Keep unused syringes in the original carton and store in the refrigerator between 2ºC and 8ºC.
  • Do not keep Dupixent at room temperature (above fridge temperature and below 25ºC) for more than 14 days. If you need to permanently remove the carton from the refrigerator, write down the date of removal in the space provided the outer carton, and use Dupixent within 14 days.
  • Do not shake the syringe at any time.
  • Do not heat the syringe.
  • Do not freeze the syringe.
  • Do not place the syringe into direct sunlight.

F.A.Qs

Find out more about Dupixent dosage, storage, and more.

MORE INFORMATION

DUPIXENT MyWay

There are several ways to find support when taking this medicine. Find out what's available.

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